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Researchers have uncovered a surprising molecular chain reaction in the brain that may play a role in some forms of autism. The study suggests that nitric oxide, a tiny signaling molecule normally involved in fine-tuning communication between brain cells, can sometimes trigger a cascade of changes inside neurons. When nitric oxide activity rises, it can alter a protective protein called TSC2, weakening an important cellular brake and allowing the mTOR pathway, which controls growth and protein production, to become overactive.
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Solid-state batteries could be safer and more energy-dense than today’s lithium-ion technology, but finding materials that allow ions to move quickly through solid electrolytes has been difficult. Researchers developed a machine learning pipeline that predicts Raman spectra and identifies a distinctive low-frequency signal linked to liquid-like ion motion inside crystals. This signal appears when rapid ion movement temporarily disrupts a crystal’s symmetry. The approach could dramatically speed up the discovery of superionic materials for advanced batteries.
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Mayo Clinic researchers have identified a rare mutation in the MET gene that can directly cause metabolic dysfunction-associated steatotic liver disease. The mutation disrupts the liver’s ability to process fat, leading to inflammation, scarring, and potentially cirrhosis. The discovery began with a father and daughter who had the disease without typical risk factors. Large-scale genomic data suggests similar rare variants may quietly contribute to the disease in many more people.
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A sweeping new study from Northwestern University reveals that scientific fraud is no longer just the work of a few rogue researchers—it has evolved into a global, organized enterprise. By analyzing massive datasets of publications, retractions, and editorial records, researchers uncovered networks involving “paper mills,” brokers, and compromised journals that systematically produce and sell fake research, authorship slots, and citations.
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A mysterious form of plague that spread across Eurasia thousands of years before the Black Death has finally revealed a crucial clue. Scientists analyzing ancient DNA discovered the bacterium Yersinia pestis in a 4,000-year-old domesticated sheep from a Bronze Age settlement in the Ural Mountains—the first time the pathogen has ever been found in a non-human host from that era. Because this early strain couldn’t spread through fleas like the medieval plague, researchers have long puzzled over how it traveled so widely.
