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A surprising stress-related signal may help the brain repair itself after injury. Researchers found that myelin-producing precursor cells rapidly release the stress hormone CRH near damaged brain tissue, helping control how those cells mature and rebuild protective nerve insulation. The same system also influences brain development and the thickness of myelin later in life. The findings could offer new clues about how early-life stress contributes to psychiatric disorders.
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A tiny superconducting engine has successfully converted heat near absolute zero into useful work, demonstrating the first cyclic quantum heat engine of its kind. Future versions could operate autonomously inside quantum computers, potentially eliminating huge numbers of costly, noise-producing microwave cables.
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Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.
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Nuclear reactors may go dark, but their fuel continues producing a faint antineutrino “glow” long after shutdown. Researchers have now detected that residual signal for the first time, finding it closely matched predictions of radioactive decay inside the reactor and nearby spent-fuel pools. The breakthrough suggests antineutrino detectors could eventually monitor reactors even when they are offline.
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Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brain’s specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the body’s immune system throughout life.