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Deep-brain recordings showed that Mounjaro and Zepbound briefly shut down the craving circuits linked to food noise in a patient with severe obesity. Her obsessive thoughts about food disappeared as the medication quieted the nucleus accumbens, the brain’s reward hub.
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Using less ipilimumab appears to make melanoma immunotherapy both safer and more effective, with dramatically better response and survival outcomes. The findings suggest that reducing side effects may be the key to maximizing the benefits of these powerful treatments.
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Researchers revealed that the microbial metabolite TMA can directly block the immune protein IRAK4, reducing inflammation and improving insulin sensitivity. The molecule counteracts damage caused by high-fat diets and even protects mice from sepsis. Since IRAK4 is a known drug target, this pathway could inspire new diabetes therapies. The study highlights how gut microbes and nutrition can work together to support metabolic health.
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Researchers have built a fully implantable device that sends light-based messages directly to the brain. Mice learned to interpret these artificial patterns as meaningful signals, even without touch, sight, or sound. The system uses up to 64 micro-LEDs to create complex neural patterns that resemble natural sensory activity. It could pave the way for next-generation prosthetics and new therapies.
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High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact within these droplet-like structures. The findings connect molecular architecture to the broader behaviors of these droplets in cells.
